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KMID : 1144420230380010001
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Acute and Critical Care
2023 Volume.38 No. 1 p.1 ~ p.7
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Extracorporeal circulation models in small animals: beyond the limits of preclinical research
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Kayumov Mukhammad
Habimana Reverien
Kim Do-Wan
Obiweluozor Francis O.
Jeong In-Seok
Cho Hwa-Jin
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Abstract
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Extracorporeal membrane oxygenation (ECMO) use has remarkably increased in recent years. Al- though ECMO has become essential for patients with refractory cardiac and respiratory failure, ex- tracorporeal circulation (ECC) is associated with significant complications. Small-animal models of ECC have been developed and widely used to better understand ECC-induced pathophysiology. This review article summarizes the development of small-animal ECC models, including the animal spe- cies, circuit configuration, priming, perioperative procedures, cannulation, and future perspectives of small-animal ECMO models.
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KEYWORD
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cardiopulmonary bypass, extracorporeal circulation, extracorporeal membrane oxy- genation, experimental research, review
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